Jojo Rabbit is a comedy-drama film written and directed by Taika Waititi , adapted from Christine Leunens 's book Caging Skies. He must then question his beliefs while dealing with the intervention of his imaginary friend Waititi , a fanciful version of Adolf Hitler with a comedic stance on the politics of the war. Waititi crafted the screenplay in , a year after his mother described the premise of Caging Skies. He rewrote the first draft , which as a rough adaptation of the dark-toned source material did not contain much comedy; it was also in the rewritten version that Adolf's character was included.
Osteoarthritis OA treatment is a major orthopedic challenge given that there is no ideal drug capable to reverse or stop the progression of the OA. In that regard, bisphosphonates have been proposed as potential disease-modifying drugs due to their possible chondroprotective effect related to obtaining a greater subchondral bone quality. However, their effectiveness in OA is still controversial and additionally, there is little evidence focused on their long-term effect in preclinical studies. The aim of this study was to evaluate the risedronate quantitative effect on articular and subchondral periarticular bone by histomorphometry, in an experimental rabbit model in an advanced stage of OA.
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Known for her work in independent films , often appearing in controversial or experimental features, Sevigny is the recipient of several accolades , including a Golden Globe Award , a Satellite Award , an Independent Spirit Award , as well as nominations for an Academy Award and three Screen Actors Guild Awards. She also has a career in fashion design concurrent with her acting work. Over the years, her alternative fashion sense has earned her a reputation as a "style icon".
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