This study investigated the cross-sectional associations between various somatic conditions in one partner and the level of distress and well-being in the spouse. A sample of 9, married or cohabiting couples with valid data on subjective well-being SWB , psychological distress Hopkins Symptom Check List SCL and somatic illness were identified. Regression analyses stratified by sex were conducted with SCL and SWB scores as dependent variables and a joint somatic score as predictor, including; stroke, cancer, angina, myocardial infarction and physical disability PD. The contribution of each somatic condition was also explored. Spouses of persons previously diagnosed with at least one somatic condition scored significantly lower on SWB and significantly higher on SCL than spouses of healthy persons, though effect sizes were small. The effect seems to be at least partly mediated by the ill partner's psychological distress. Abstract This study investigated the cross-sectional associations between various somatic conditions in one partner and the level of distress and well-being in the spouse.